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How Long Does Tramadol Stay in Your System

Tramadol is a prescription opioid that is prescribed for pain relief. When used as prescribed, tramadol is a safe and effective medication for treating moderate to moderately severe pain. However, misuse of the drug can increase the risk of developing dependence and addiction.

Understanding how the drug works, and how long it stays in your system can help you take the right precautions to avoid any adverse drug interactions and decreases the risk of a possible overdose.

What Is Tramadol?

Tramadol is a synthetic opioid analgesic medication that is prescribed to treat moderate to severe pain. Similar to other prescription pain medications, the drug works by binding on opioid receptors in the central nervous system and the brain to block pain signals. Tramadol also increases norepinephrine and serotonin, two neurotransmitters that are associated with our pain perceptions.

It is typically sold under the brand names Ultram, Ryzolt, and Ultram and is available in different forms. The immediate release begins to work about an hour after the first consumption and peaks around two to four hours after it has been taken. The extended form of tramadol releases dosages over a longer period of time and therefore stays longer in the system.

Tramadol is not as potent as other opioids and is classified as a Schedule IV drug by the Food and Drug Administration (FDA). This means that it has a low risk of abuse and addiction, although a tramadol addiction is possible if there is a misuse of the drug.

Side Effects

Taking tramadol comes with a risk of side effects ranging from mild to severe. The risk of side effects increases depending on the dosage taken. Common side effects include:

  • Dizziness
  • Headache
  • Irritability
  • Dry mouth
  • Fatigue
  • Drowsiness
  • Constipation
  • Itching
  • Sweating

How Long Does Tramadol Stay in Your System?

The length of time that tramadol stays in a person’s system is dependent on a variety of individual factors, as well as the type of drug testing method. However, on average, it is believed that it takes around about a day and a half to two days for the drug to be eliminated from your system.

Tramadol’s half-life, meaning the time that it takes for half of the dose to be eliminated from the body, is around five to nine hours, and this is longer if you have consumed multiple doses.

The body breaks down tramadol in the liver where it is released in the urine. Around 30% of the dose is released through the urine unchanged, whereas the rest is converted into different metabolites before being excreted.

Different Drug Tests and When They Detect Tramadol

Tramadol is not detectable in all standard drug screening tests; however, advanced screening panels are used to detect the drug. Tramadol can be detected at different points, after the last dose of the drug, depending on the type of drug test that is being used.

Blood Tests

A blood test is the quickest in detecting the drug after it has been consumed, and typically this is up to forty-seven hours after the last dose.

Saliva Tests

A saliva test can detect tramadol for up to two days after the drug has been taken.

Urine Tests

Standard urine drug screens do not typically test for tramadol or other similar opioids. An extended opioid panel will most likely be used to detect tramadol. Urine tests will be able to detect the drug for one to four days after use.

Hair Tests

Hair testing is known to detect drugs long after the last dose. If a hair test is used, it will be able to detect tramadol for as long as ninety days.

Factors That Influence How Long Tramadol Remains in the Body

Although the amount of time that tramadol will stay in your system can be estimated from the drug’s known half-life. There are individual factors that affect how long the body takes to eliminate the drug.


It is believed that tramadol will stay in an older person’s body longer than somebody who is younger. It was found that the half-life of the drug increases to seven hours in those who are over the age of seventy-five. Tramadol reaches higher levels of concentration in the blood of people in this particular age group.


If you have a slower metabolic rate, then tramadol will take a longer period of time to break down in the body. Diet, body composition, and activity levels all affect metabolism rates.

Organ Function

Tramadol is metabolized by enzymes that are present in the liver and are then processed through the kidneys. If there are any impairments in the liver or the kidneys, then this would increase how long tramadol stays in the system as it would take longer to break down.

Dosage and Type of Medication

If you have taken multiple doses of the drug, then tramadol will take longer to leave the body. Tramadol is available in two forms: immediate or extended-release. The extended-release will stay in your system for a longer time because the drug is slowly released over a lengthier period. Similarly, if you have been taking the drug for a short period of time, the body will clear it out quickly as it has had less time to build up within the body.

Tramadol Addiction

According to the World Health Organization, if you take tramadol as prescribed by the doctor, it is a safe and effective medication.

However, tramadol is habit forming which means that you can develop a psychological and physical dependence on the drug. This risk is increased if tramadol use is outside of the recommended dosage.

If you have become dependent on the drug, then it is likely that you will experience withdrawal symptoms if you decide to suddenly stop taking the drug or if you reduce your consumption. At times, these symptoms can be difficult to manage. Treatment centers offer guidance and support to help you ease withdrawal symptoms.

One of the most adverse risks of drug abuse is the risk of a tramadol overdose. The following symptoms could indicate an overdose:

  • Constricted pupils
  • Low blood pressure
  • Seizures
  • Decreased heart rate
  • Slowed breathing
  • Cardiac arrest
  • Clammy skin
  • Intense drowsiness

The risk of an overdose increases if other drugs that depress the central nervous system have also been consumed. This includes other opioid drugs or alcohol.

If you spot any of these symptoms in yourself or a loved one, it is important that you seek professional medical assistance by calling 911. An overdose requires immediate medical attention. Similar to other opioid medications and drugs, an overdose can be treated with the administration of Naloxone if it is detected at the right time.

Treatment at NP Addiction

Neuro-Psychiatric Addiction Clinic (NPAC) is among the leading treatment and detox centers in the country. We offer a range of addiction treatment options delivered with the utmost compassion and care.

The United States is battling an opioid crisis that sees millions of people abusing opioids each year. If you are living with opioid dependence, we can support you and provide a safe space where you are able to effectively withdraw from opioids while receiving personalized medical care with long-term support.

We understand that treatment for mental health disorders or substance abuse disorders is not a one-size-fits-all approach. This is why we pride ourselves on giving the highest quality of care through an individualized treatment program that includes specialized and pioneering treatments, alongside traditional therapy methods. We want to ensure that the treatment process is fit for your needs to ensure you are able to reach your recovery goals.

If you believe you or a loved one is living with a substance abuse disorder, then reach out today to see how we can help you.

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To find out more contact our team


Samantha Kelly​

Director of National Business Development & Admissions Coordinator

I am a dedicated and passionate professional with extensive experience in business development Admissions and marketing. I have an incredible passion for showing others that there is a light at the end of this dark tunnel if someone truly wants it.
Being in recovery myself I understand the struggles of addiction and alcoholism. I Started this Career path in 2009. With multiple years of experience, I bring a multi-faceted approach and am always seeking new ways to make a difference in the lives of those I work with.

Kim L. Buckner


As a Substance Abuse Motivational Speaker, Pastor, Peer Advocate, and Facilitator. Kim helps clients avoid relapse by understanding their triggers. Those people, places and things that can cause craving, as well as internal triggers like feelings, thoughts, or emotions. Kim also clients with identifying and building healthy relationships now that they’re clean and sober.

Kim’s background includes extensive experience as a motivational speaker and work in faith-based organizations helping youth and adults alike. He says he is motivated by giving back to the community, understanding, and not judging who she comes into contact with. Kim’s favorite quote is by Dr. Raymond Johnson: “The respect given to others rebounds to the giver to deny the scared in the Other is to deny it in oneself.”

Caty Burns


Caty graduated from Indiana University Bloomington in 2015 with a Bachelor of Arts in Psychology and minors in Counseling and History. Throughout her undergrad, she worked at the local CASA program, supporting volunteers advocating for children who had experienced abuse and neglect. Caty worked for seven years at a community mental health center (CMHC), partnering with children, adults, and families.

During those seven years, she taught life and coping skills as well as behavior management, provided case management and peer recovery services, and facilitated treatment teams that included the client, family, providers, and community members. I have also worked at an IOP providing group therapy services. She is currently working towards my Master of Social Work.

In her free time, Caty enjoys reading, especially historical fiction, spending time outdoors and having movie nights with her family. Disney World is her happy place, and she dreams of living among the elephants.

Madison Knowles

Mental Health Therapist

My name is Madison Knowles, I am a Mental health therapist at NPAC. I am a single-mother of two and I have a daughter who is globally delayed and has been diagnosed with autism. I have been in this industry since I was 16 years old, as I was fascinated with human behavior. I obtained my masters in applied behavioral analysis and started off working with people with disabilities. I then found my love for counseling when I worked with juveniles who had mental health and substance use issues. I then decided to go back for my mental health therapy license after that and working in a forensic treatment center. I went on to obtain my therapy credentials and since 2017, I have also been working on my PhD in forensic psychology in which I am currently working on my dissertation. I am inspired by change and how resilient people can be. My favorite inspirational quote is “Some will, Some won’t, So what, NEXT!!!” This quote has inspired me to try, try, and try again no matter how hard life gets, someone will give you a chance eventually. As a therapist at NPAC, I have been given the opportunity to work with diverse populations such as in substance use and mental health and I am known for my work with people on the schizophrenic spectrum as well as with other clients with other severe conditions including personality disorders.

Megan Carmona, LMHC

Lead Therapist

Our Lead Therapist, Megan, is a bilingual Licensed Mental Health Counselor who specializes in working with adults who struggle with addiction, anxiety, depression, and trauma. As Lead Therapist, she provides individual, family, and group therapy sessions to our clients.  Megan says “I am very passionate about therapy, especially about supporting my clients in exploring their strengths and identity. My goal is to provide individuals with the tools that can help them achieve independence in coping with their challenges and facilitating personal development.” In her free time, Megan enjoys watching docu-series and playing video games with her family. Her dream is to own acres of land so she can care for vulnerable animals, especially old dogs, cats, and horses. 

Kristen Bensley

Primary Clinician

As Primary Clinician, Kristen works with all aspects of our clinical team, from case management to primary therapy.  She has broad experience working in the mental health field. Prior to joining our team at the Neuro Psychiatric Addiction Clinic, Kristen was part of the team awarded the Evernorth Behavioral Health Center of Excellence Designation by Cigna. She says her motivation is to help people rediscover who they are and become excited about the future and all the possibilities life offers. Kristen’s favorite quote is: “You can’t go back and change the beginning, but you can start where you are and change the ending.”

Ronn Daigle, MSW

Therapist, Utilization Review Clinician

Ronn Daigle services as a Therapist and Utilization Review Clinician at the Neuro Psychiatric Addiction Clinic. He has been working in the field of substance use disorder treatment since 2011, with experience in all facility-based levels of care. Ronn earned, both an Associate of Arts in Psychology (2013) and Bachelor of Science in Human Services, with an Addiction Studies Concentration (2015) from Indian River State College. 

Ronn additionally earned a Master of Social Work degree in 2021 and is a current Registered Clinical Social Work Intern working toward licensure (LCSW). He describes himself as detail oriented, and solution focused.

Ronn says: “There is nothing more fulfilling than working with someone who doesn’t believe in himself or herself, and being there in the moment with them when the belief begins. We work with individuals who come to us at a point and time in their respective lives where they do not believe that change for others is possible; let alone for themselves…throughout the process they eventually come to a point where they realize that change is not only possible, but achievable.”

Erika Melecio, LMHC, MCAP, CEI

Assistant Clinical Director

Erika Melecio, LMHC, MCAP, CEI is the Assistant Clinical Director at Neuropsychiatric Addiction Clinic who specializes in the treatment of LGBTQ, addiction, as well as mental health disorders ranging from depression and anxiety, to Bipolar Disorder, trauma, personality disorders, psychotic disorders, and eating disorders. Erika utilizes a number of modalities including Cognitive Behavioral Therapy, Solution Focused Therapy, Motivational Interviewing, Dialectical Behavioral Therapy, and Mindfulness amongst others. Erika has been in practice for close to a decade and has earned her license in Mental Health Counseling, as well as being a Master’s Certified Addiction Professional. Erika has worked with many individuals including couples counseling and family therapy, and is fluent in Spanish.
Throughout my years of practice, one of the things I enjoy helping people find is inner peace. Whether you are in the deepest parts of depression, overrun by your anxiety, controlled by your addiction, or there are certain issues in your life that are negatively impacting your ability to function, and have a happy, healthy life, maybe now is the time to talk about it. I am a big believer in empowerment, working hard in therapy, and utilizing different techniques to help you regain that inner peace that may have been lost along the way. I want to work with you as a team because with two people, absolutely everything is possible. I want to be there as a therapist, to help build you up, support you, but also help you be honest with yourself and accountable. At the end of the day, when all is said and done, my biggest goal for you is going to be simple….for you to no longer need my services. Why? Because if you no longer need my services, it means that you have regained your peace, you have regained your strength, you have regained your confidence. It means that you now have the tools to address any issues that try to derail you, and best of all, you will have the insight to overcome and thrive. So let’s begin this journey together, and get you to the place you want to be, emotionally, mentally, psychologically, and in your sobriety.

Aurelio Ayuso, MSW, LCSW, CAP, ICADC

Clinical Director

Aurelio has worked with those that suffer from the disease of addiction in adults and juveniles alike for over 10 years, beginning in the United States Navy where he proudly served for 20 years, working with those that were succumbed by addiction due to trauma and continuing his passion for helping those in need locally in Central Florida.

He specializes in both Addictions and Trauma, he has worked first as a therapist then as the clinical supervisor to both the Juvenile and Adult Drug Court programs in Brevard County. Aurelio has been instrumental in developing substance abuse treatment programs directly tailored to help those that also suffer from complex trauma due to their addiction. He has been recognized by several organizations for his forward thinking and ability to tailor treatment to individuals in the most restrictive environments.

Mr. Ayuso received his Graduate Degree in Clinical Social Work from the University of Central Florida in Orlando. He is a Licensed Clinical Social Worker as well as Certified Addictions Professional in the State of Florida, and Internationally Certified Alcohol & Drug Counselor. Aurelio specializes in the treatment of Addiction, Trauma, and Abandonment using strength based strategies deeply rooted in Solution Focused, and Mindfulness Therapies. At the Neuropsychiatric Addiction Clinic he passionately develops holistic curriculums that foster the belief that through addressing the mind, body, and spirit together, the Disease of Addiction can be addressed successfully.

Robert Lehmann, MHSA

Chief Operating Officer

Bob Lehmann is the Chief Operating Officer at the Neuro Psychiatric Addiction Clinic. He has a Master’s Degree in Human Services Administration with a concentration in Mental Health Administration and over twenty-five years of experience as a senior executive at addiction and mental health treatment facilities.

One of the reasons for his commitment to excellence in addiction treatment was his experience related to family members who suffered from the disease of addiction. Bob has been actively involved in community organizations throughout his career. Recently he was one of the founders of the Florida Addiction Treatment Coalition (FATC) and is its present Vice President. FATC was designed to bring together treatment executives in Florida to advocate on behalf of treatment facilities and the clients they serve adhering to a foundation of integrity and service excellence.

Jose R. Toledo, M.D.

Medical Director

A well-rounded and accomplished individual, Jose R. Toledo, M.D., is the Medical Director of Neuro Psychiatric Addiction Clinic.

Dr. Toledo is a neurologist with 25 years of experience and has been in private practice since 1991 on the Treasure Coast of Florida. He completed his neurology training at the State University of New York and his Fellowship training at the University of Pittsburgh in Epilepsy and Clinical Neurophysiology.

He also completed 24 months of acute inpatient psychiatry at the Western Missouri Mental Health Center, University of Missouri in Kansas City. In 2008, Dr. Toledo participated in and was certified in the continuing medical education activity entitled “Buprenorphine and Office-Based Treatment of Opioid Dependence” from The Medical University of South Carolina during which began his quest to found and head Neuropsychiatric Addiction Clinic.

Dr. Toledo is a brain specialist with particular competence in addiction medicine and out-patient detoxification treatment and integrates the fields seamlessly. He is certified to prescribe Buprenorphine (Suboxone). He incorporates his background in neurology into the addiction field. Dr. Toledo is member/fellow of The American Medical Association, The Florida Medical Association and The American Society of Addiction Medicine